Research Paper: Toxicant
MOS 5425 – Advanced Toxicology
This paper will compare and contrast a toxin that affects the nervous system, one that affects the endocrine system and another that affects the cardiovascular system. Identify the characteristics that are shared by these toxins and characteristics of these toxins make these toxins vulnerable to toxicity of these specific systems?
Central Nervous System
Environmental contamination has exposed humans to various metal agents, including mercury. This exposure is more common than expected, and the health consequences of such exposure remain unclear. Mercury in the past was used in a numerous different ...view middle of the document...
The Canadian Centre for Occupational Health and Safety cited that the most prominent and well documented health concerns from exposure to endocrine disruptors are reproductive and developmental effects. Some of the disorders that have been seen in animal studies include oligospermia (low sperm count), testicular cancer, and prostate hyperplasia in adult males; vaginal adenocarcinoma, disorders of ovulation, breast cancer, and uterine fibroids in adult females. Disruption to thyroid functions, obesity, bone metabolism and diabetes are also linked to exposure endocrine disruptors (Endocrine Disruptors, 2013).
For decades, the toxic effects of mercury were linked mainly with the central nervous system; however, inorganic mercury also creates profound cardiotoxicity. Researcher have shown that mercury concentrations in hair can reached up to 150μg/g in populations living in the Amazon basin. Furthermore, Azevedo and his team (2012) discovered that nearly all of the inhabitants of the 40 cities covered in their study registered blood concentrations above the reference values. In this population, it was demonstrated that exposure to mercury by frequent consumption of fish has a strong positive connection with increased arterial blood pressure. In contrast, other studies show that mercury exposure could increase risk of...