Role of Nano medicine in anti bacterial therapy and diagnosis against antibiotic resistant bacteria
Adityaa sahay,Neda farooque,Shilpi Srivastava ,Rachna Chaturvedi*
Amity Institute of Biotechnology, Amity University Uttar Pradesh (Lucknow Campus), Gomti Nagar Extension, Lucknow 227105, India
Nanomedicine an outcome of nanotechnology, refers to extremely specific medical involvement protection and improvement of human health using at the molecular scale for a variety of life threatening disease . Recent methods involved in bacterial diagnostics are incompetent as they lack speed and ultra sensitivity and cannot be performed on site. The invention of new and revolutionary ...view middle of the document...
In the United States alone, MRSA kills more than 19,000 people a year. The IBM nanomedicine polymer program "ninja polymers" - sticky nanostructures that move quickly to target infected cells in the body, destroy the harmful content inside without damaging healthy cells in the area, and then disappear by biodegrading.Alternatively, silver nanoparticles have adverse effects on cells such as the production of reactive oxygen species which are toxic to both bacteria and eukaryotic cells . In contrast, the cytotoxicity of gold nanoparticles is quite low, and they have been used for medical imaging and have served as scaffolds for drug delivery.
Mechanism Of Work
Through the precise tailoring of the ninja polymers, researchers were able to create macromolecules - molecular structures containing a large number of atoms - which combine water solubility, a positive charge, and biodegradability. When mixed with water and heated to normal body temperature, the polymers self-assemble, swelling into a synthetic hydrogel that is easy to manipulate, the hydrogel's positive charge attracts negatively charged microbial membranes, like stars and planets being pulled into a black hole. However, unlike other antimicrobials that target the internal machinery of bacteria to try to prevent it from replicating, this hydrogel destroys the bacteria by rupturing the bacteria's membrane, rendering it completely unable to regenerate or spread.The hydrogel is comprised of more than 90 percent water, making it easy to handle and apply to surfaces. It also makes it potentially viable for eventual inclusion in applications like creams or injectable therapeutics for wound healing, implant and...